PE-452787-1 THE RELATIONSHIP BETWEEN VENTILATORY ANAEROBIC THRESHOLD AND ARRHYTHMIA ONSET IN PATIENTS WITH CATECHOLAMINERGIC VENTRICULAR TACHYCARDIA

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disease associated with malignant arrhythmias, typically developing at high heart rate (HR) and catecholamine states. Patients are often restricted from exercise. Cardiopulmonary exercise testing (CPET) used to diagnose monitor patients ensure HR-associated arrhythmias adequately blunted on beta blockers (BB). In addition peak HR, CPET can also determine the ventilatory anaerobic threshold (VAT), point which body shifts aerobic metabolism generating lactic acid as byproduct. VAT commonly in prescribing intensity those without but has not been evaluated CPVT patients. This transition could be useful clinically determining more precise limits CPVT. To assess if there an association between development of arrhythmia during diagnosed retrospective cohort study all completing our institution July 2017 through September 2022. was calculated utilizing V-slope method. Simple ectopy defined single, uniform premature complexes (PVCs) complex PVCs or tachycardia. The HR time first developed noted. There were 44 CPETs completed by 10 (19.8±10.4 years-old test; 50% male) genetically-confirmed Most tests occurred while patient BB therapy (39/44). had simple 34 25. No before any test (Figure 1). Average (101.4±14.7 bpm) below both (122.1±14.3 (136.8±18.4 developed. each lower group than BB. These trends similar initial diagnosis their subsequent tests. seem reach prior onset ectopy. Anaerobic may play role arrhythmogenicity these patients, possibly due production. If confirmed larger studies, activity restrictions liberalized allow low-intensity goals